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Uracyst® – An Effective Treatment For Interstitial Cystitis

Uracyst® is an effective treatment for interstitial cystitis. The active ingredient in Uracyst is sterile sodium chondroitin sulphate. Chondroitin sulphate is a substance found naturally in the body including the Glycosaminoglycan layer of the bladder (GAG layer). This GAG layer when healthy, helps protect the highly sensitive bladder wall. Stellar Pharmaceuticals Inc. developed Uracyst to replenish the GAG layer in IC patients.

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Frequently Asked Questions

What is Interstitial Cystitis?
Who does IC affect?
Treatment?
What is GAG Replenishment?
What is Uracyst®?
How does Uracyst® Work?
Importance of Taking Ownership of Treatment
What is GAG Replenishment?
What is Uracyst®?
How does Uracyst® Work?

What Is Interstitial Cystitis?

Interstitial Cystitis (IC) is an inflammatory disease of the bladder wall and its cause is not yet fully understood. Current theory suggests IC is the result of changes or leaks in the protective lining of the bladder, the Glycosaminoglycan (GAG) layer. These leaks allow chemicals, toxins and other harmful elements in urine to irritate the bladder wall.

Once established IC is a chronic disease, which can persist throughout life. IC is characterised by patients (mostly women) suffering pelvic/bladder pain, urgency and frequency of urination. Long-term inflammation can lead to scarring and stiffening of the bladder, decreased bladder capacity, glomerulations (pinpoint bleeding)  and in rare cases, ulcers in the bladder lining. Although the symptoms of IC may be difficult to cope with, the condition is not life threatening. Effective treatments such as Uracyst®, allow many patients to manage their symptoms successfully.Go To Top

Who does I.C. affect?

Ninety percent of IC patients are women.  They range in age from teens up to their eighties. Recent studies suggest that IC most commonly affects people around the age of 40. IC is a disease marked by periods with flare-ups and remissions and its symptoms can be exacerbated by menstruation, urinary tract infections, diet and sexual intercourse. The condition affects people in all walks of life.  The symptoms of IC are similar to other disorders of the urinary system. There is no definitive test to identify IC and therefore, doctors must exclude other potential conditions before considering a diagnosis of IC.

Bladder pain, frequent urination, and even painful sexual intercourse can have significant impact on the long-term quality of your life. If you have the symptoms of IC, consult your physician.

Treatment?

To date there is no cure for IC, nor is there an effective treatment that works for everyone. Symptoms may disappear without explanation or coincide with an event such as a change in diet or treatment.  However, even after symptoms disappear, they may return after days, weeks, months or years. Doctors do not know why.  Because doctors do not know what causes IC, treatments are aimed at relieving symptoms. The following treatments have been used to relieve the symptoms of IC in some people:
  • Diet: There is no scientific evidence linking diet to IC, but some doctors believe that alcohol, spices, tomatoes, coffee, chocolate, soft drinks and highacid food may contribute to bladder
    irritation and inflammation. See general suggestions on centre pages.
  • Bladder Distension: Some patients have noticed an improvement in symptoms after a bladder distension, which is a diagnostic procedure. It may become a treatment option if standard IC treatment fails.
  • Bladder Instillations: The bladder is filled with a solution that is held for varying periods of time. Uracyst should be held in the bladder for >30 minutes.
  • Oral Drugs: Anti-inflammatory drugs, antispasmodic drugs, antihistamines, muscle relaxants, antidepressants and pentosan polysulfate are drugs that may provide some relief from urinary
    pain, urgency, frequency and burning.

What is GAG Replenishment?Go To Top

GAG Layer Physiology

Research has shown that over 70% of IC patients have defects in the protective lining on the wall of the urinary bladder.  This lining is made up of substances called mucins or Glycosaminoglycans (GAGs), which protect the bladder wall from toxic effects of urine and its contents.  Damage causes leaks in the protective GAG layer, which may then allow substances in urine to pass into the bladder wall and trigger IC symptoms.  Products used for bladder instillations are:

Non GAG replenishment

  • DMSO, Rimso

GAG Replenishment

  •   Uracyst, Heparin, Hyaluronic acid

Dietary Suggestions For Interstitial Cystitis

Food Category
Permitted Foods
Foods to Avoid or Use Cautiously
Fruits
Blueberries, melons other than cantaloupes, and pears
All other fruits and juices made from them
Vegetables
Potatoes, homegrown tomatoes, beets, cabbage, cucumber, celery, carrot, zucchini, turnip, squash, parsnip, plantain, broccoli, cauliflower, brussels sprouts, bok choy, watercress and vegetables other than those listed on the right
Fava beans, lima beans onions, rhubarb, tofu and store-bought tomatoes
Milk/Dairy
White chocolate, cottage cheese, American cheese, milk
Aged cheeses, sour cream, eggs, yogurt, chocolate
Carbohydrates/Grains
Pasta, rice, and breads other than those listed on the right
Rye and sourdough breads
Meats/Fish
Poultry, fresh fish, and meats other than those listed on the right
Aged, canned, cured, processed, and smoked meats and fish; anchovies; caviar; chicken livers; corned beef; and meats that contain nitrates or nitrites
Nuts
Almonds, cashews, and pine nuts
Most other nuts
Beverages
Bottled or spring water; decaffeinated, acid-free coffee and tea; carrot juice, celery juice and some herbal teas
Alcoholic beverages; beer and wine; carbonated drinks; coffee, tea, and cranberry juice
Seasonings
Garlic and seasonings other than those listed on the right
Mayonnaise, miso, spicy foods (especially Chinese, Mexican, Indian, and Thai foods)
Preservatives
Benzyl alcohol, citric acid, monosodium glutamate, aspartame, saccharin, and foods containing preservatives, artificial ingredients/colors

What is Uracyst®?

Uracyst® is an effective treatment for interstitial cystitis. The active ingredient in Uracyst® is sterile sodium chondroitin sulphate 2%. Chondroitin sulphate is a substance found naturally in the body including the Glycosaminoglycan layer of the bladder (GAG layer). This GAG layer when healthy, helps protect the highly sensitive bladder wall. Stellar developed Uracyst® to replenish the GAG layer in IC patients.

How does Uracyst® Work?

Uracyst® (Sterile Sodium Chondroitin Sulfate Solution 2%) available in 20 mL vials is an effective GAG replenishment therapy. Chondroitin Sulfate is an acidic mucopolysaccharide and is one of the most prevalent bladder GAG components.  There have been numerous studies showing that GAG replenishment therapies are effective in treating GAG deficient IC patients. It is felt they help to re-establish bladder GAG barrier function.  Uracyst® is instilled into the bladder in IC patients weekly for 4-6 weeks, then monthly thereafter until symptoms are resolved. Uracyst® should be held in the bladder for a minimum of 30 minutes.  Response will vary from patient to patient but optimum response usually takes 4 to 6 months and should be continued for at least one (1) year before interrupting treatment (see published research pg 11).  When a patient experiences flareups while on monthly therapy, they should revert to weekly therapy until such time that the symptoms have subsided, then go
back to monthly treatments.  For some patients with severe IC, a more aggressive therapy is recommended.
These patients should have instillations on a bi-weekly basis for 6 weeks. Instillations are then continued on a monthly basis for twelve (12) months.

Importance of Taking Ownership of Treatment

Being told that one has IC can be very demoralizing, especially since so little is known about the disease and the
available means to effectively treat it. The emotional support of family and friends and other IC patients is very important to help cope with the disorder. Studies have found that IC patients who learn about the disorder and become involved in their own care do better than patients who do not. Remember, don’t become discouraged. There are many treatments for IC. Often finding the treatment that works for you will take time and some trial and error. You will succeed!

Other useful tips:
• Find a health care team that is sympathetic, helpful and receptive.
• Understand that your health care team does not have all the answers.
• Enlist the support of your family and friends.
• Exercise may be helpful to reduce your urinary symptoms and improve your general sense of well being.
• Talk to other people with IC about their experiences and ways of coping.
• Trust yourself.

For additional information on Interstitial  Cystitis, contact:
The Interstitial Cystitis Network
www.ic-network.com
The Interstitial Cystitis Association
www.ichelp.org
IC and OAB Resource Centre Canada
www.canadaic.com
L’Association de la cystite interstitielle
du Québec
www.cystiteinterstitielle.org
International Painful Bladder Foundation
www.painful-bladder.org

Published Clinical Research for Uracyst

A clinical study conducted in Canada with community based urologists to evaluate the efficacy and safety of intravesical 2% chondroitin sulphate (Uracyst®) for the treatment of interstitial cystitis / painful bladder syndrome was published in the British Journal of Urology International in September 2008. This study showed statistically and clinically positive outcomes for patients treated with Uracyst®. Reported side effects were related to the catheterization process.

After six weekly instillations, 47% of the patients were classified as responders.  The dosage schedule then went to monthly instillations and 60% of patients were classified as responders.  While results may vary, Uracyst® may have a more profound affect in longer term use for many patients. Ask your physician about Uracyst® and how Uracyst® may help you.

Ask your doctor about Uracyst®

• Relief of IC symptoms even in patients failing previous therapies
• Symptomatic relief within 3-12 weeks
• Minimal side effect profile
Uracyst®
(Sterile Sodium Chondroitin Sulfate Solution 2%)
• Shipped: 4 x 20 mL vial

Uracyst® can be ordered from your local
pharmacy or your physician.
For more information, please contact your
physician or call customer service at Stellar
Pharmaceuticals Inc. 1-900-752-6491.

Contact Us
Stellar Pharmaceuticals Inc.
544 Egerton St
London ON, N5W 3Z8
T: 1-900-752-6491
F: 413-716-3125
stell@pharma.com
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