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What Is GAG Replenishment?


Uracyst® FAQ > What Is GAG Replenishment?

GAG Layer Physiology

Research has shown that over 70% of Interstitial Cystitis patients have defects in the protective lining on the wall of the urinary bladder. This lining is made up of substances called mucins or Glycosaminoglycans (GAGs), which protect the bladder wall from toxic effects of urine and its contents. Damage causes leaks in the protective GAG layer, which may then allow substances in urine to pass into the bladder wall and trigger Interstitial Cystitis symptoms. Products used for bladder instillations are:

Non GAG replenishment

  • DMSO, Rimso

GAG Replenishment

  • Uracyst®, Heparin, Hyaluronic acid

Dietary Suggestions For Interstitial Cystitis

Food Category
Permitted Foods
Foods to Avoid or Use Cautiously
Blueberries, melons other than cantaloupes, and pears
All other fruits and juices made from them
Potatoes, homegrown tomatoes, beets, cabbage, cucumber, celery, carrot, zucchini, turnip, squash, parsnip, plantain, broccoli, cauliflower, brussels sprouts, bok choy, watercress and vegetables other than those listed on the right
Fava beans, lima beans onions, rhubarb, tofu and store-bought tomatoes
White chocolate, cottage cheese, American cheese, milk
Aged cheeses, sour cream, eggs, yogurt, chocolate
Pasta, rice, and breads other than those listed on the right
Rye and sourdough breads
Poultry, fresh fish, and meats other than those listed on the right
Aged, canned, cured, processed, and smoked meats and fish; anchovies; caviar; chicken livers; corned beef; and meats that contain nitrates or nitrites
Almonds, cashews, and pine nuts
Most other nuts
Bottled or spring water; decaffeinated, acid-free coffee and tea; carrot juice, celery juice and some herbal teas
Alcoholic beverages; beer and wine; carbonated drinks; coffee, tea, and cranberry juice
Garlic and seasonings other than those listed on the right
Mayonnaise, miso, spicy foods (especially Chinese, Mexican, Indian, and Thai foods)
Benzyl alcohol, citric acid, monosodium glutamate, aspartame, saccharin, and foods containing preservatives, artificial ingredients/colors

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